Difficulty Treating Canine Diabetes Insipidus
by Bruce Ferguson
Ceasar presented as a 10 year old neutered male white German Shepherd dog with nephrogenic diabetes insipidus. Central diabetes insipidus is caused by reduced secretion of antidiuretic hormone (ADH). When target cells in the kidney lack the biochemical machinery necessary to respond to the secretion of normal of increased circulating levels of ADH, nephrogenic diabetes insipidus results. Affected animals excrete large volumes of hypotonic urine and drink equally large amounts of water.
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